Aging Exchange_Purdue University_Spring 2024

doctor first 1 . Because experts are unsure when RSV and other viruses will emerge, they recommend getting your vaccines early -- between September and October each year -- and to get your COVID - 19 and flu shot at the same time 4 . The vaccines should be free for those with insurance. Works Cited 1 https://www.usnews.com/news/health - news/articles/2023 - 06 - 29/ older - americans - can - get - rsv - vaccine - this - fall - after - speaking - with - their - doctor - cdc - says 2 Papi, A., Ison, M. G., Langley, J. M., Lee, D. - G., Leroux - Roels, I., Martinon - Torres, F., Schwarz, T. F., van Zyl - Smit, R. N., Campora, L., Dezutter, N., de Schrevel, N., Fissette, L., David, M. - P., Van der Wielen, M., Kostanyan, L., & Hulstrøm, V. (2023). Respiratory syncytial virus prefusion F protein vaccine in older adults. New England Journal of Medicine, 388(7), 595 – 608. https:// doi.org/10.1056/nejmoa2209604 3 Hu, W., Fries, A. C., DeMarcus, L. S., Thervil, J. W., Kwaah, B., Brown, K. N., Sjoberg, P. A., & Robbins, A. S. (2022). Circulating trends of influenza and other seasonal respiratory viruses among the US Department of Defense personnel in the United States: Impact of the COVID - 19 pandemic. International Journal of Environmental Research and Public Health, 19(10), 5942. https://doi.org/10.3390/ ijerph19105942 4 https://www.nytimes.com/article/flu - covid - rsv - vaccines.html 5 Graham, B. S. (2023). The journey to RSV Vaccines — heralding an era of structure - based design. New England Journal of Medicine, 388 (7), 579 – 581. https://doi.org/10.1056/nejmp2216358 6 Walsh, E. E., Pérez Marc, G., Zareba, A. M., Falsey, A. R., Jiang, Q., Patton, M., Polack, F. P., Llapur, C., Doreski, P. A., Ilangovan, K., Rämet, M., Fukushima, Y., Hussen, N., Bont, L. J., Cardona, J., DeHaan, E., Castillo Villa, G., Ingilizova, M., Eiras, D., … Schmoele - Thoma, B. (2023). Efficacy and safety of a bivalent RSV prefusion F vaccine in older adults. New England Journal of Medicine, 388(16), 1465 – 1477. https://doi.org/10.1056/nejmoa2213836 Original photo source; Experimental respiratory syncytial virus vaccine prompts antibody surge | National Institutes of Health (NIH) Laurel Williams is the CALC undergraduate student service Program Assistant. She is completing her degree in Speech, Language, & Hearing Sciences at Purdue.

RSV Vaccine cont.

targeted by a vaccine 5 . The success of this structure - based vaccine design became useful during the COVID - 19 pandemic. Technical advances in RSV research, that had taken decades, were able to be rapidly utilized to develop a safe and effective vaccine for COVID - 19 in a much shorter timeline.

After the success of the COVID - 19 vaccine, new RSV vaccines have been developed and were approved by the FDA for adults aged 60+ in May 2023 4 . There are two vaccines made by GSK and Pfizer, AREXVY and ABRYSVO. Both companies have found that their vaccine is effective against typical, acute, and severe RSV - associated lower respiratory tract infections 2,6 . Like most vaccines, the efficacy increases with severity of the disease; the vaccine is most effective at preventing severe infections 6 . Both vaccines were also shown to be effective in the prevention of RSV related infections for one viral season 2,6 . The CDC recommends that those 60 years and older who are eligible for the vaccine discuss it with their Image 1: Electron Microscope Image of RSV colorized blue with anti - RSV antibodies colorized yellow being cast off from human lung cells 1 .

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